NextSeq 550AR测序仪 / 耗材 / 分析软件 / 整体解决方案

公司的核心团队具有资深的基因组专业背景和丰富的行业经验,对相关技术和产业的现状、发展趋势等具有深刻的认识和理解。核心团队成员具有优秀的学术素养,目前已在 Nature、Science 等顶尖学术期刊发表多篇学术论文。


团队成员自2007 年起开始负责国内新一代测序实验平台的搭建,是我国测序平台发展的见证者和骨干力量。安诺优达以此为核心,集合了国内外一大批优秀的高通量测序技术的骨干研发人员,吸引了来自生物学、医学、数学、计算机、物理、化学等不同行业和领域的一流人才,并形成了由博士、硕士和学士等组成的合理人才队伍梯队,共同推动公司的研发和产业快速健康发展。



1. Giorgetti L, Galupa R, Nora EP, Piolot T, Lam F, Dekker J, Tiana G, Heard E. Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription[J]. Cell, 2014, 157(4):950-63.
Edith Heard 近年发表文章PubMed链接 >>

2. Heard E, Martienssen RA. Transgenerational epigenetic inheritance: myths and mechanisms[J]. Cell, 2014, 157(1):95-109. 

3. Gendrel AV, Attia M, Chen CJ, Diabangouaya P, Servant N, Barillot E, Heard E. Developmental dynamics and disease potential of random monoallelic gene expression[J]. Dev Cell, 2014, 28(4):366-80. 

4. Schulz EG, Meisig J, Nakamura T, Okamoto I, Sieber A, Picard C, Borensztein M, Saitou M, Blüthgen N, Heard E. The two active X chromosomes in female ESCs block exit from the pluripotent state by modulating the ESC signaling network[J]. Cell Stem Cell, 2014, 14(2):203-16. 

5. da Rocha ST, Boeva V, Escamilla-Del-Arenal M, Ancelin K, Granier C, Matias NR, Sanulli S, Chow J, Schulz E, Picard C, Kaneko S, Helin K, Reinberg D, Stewart AF, Wutz A, Margueron R, Heard E. Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome[J]. Mol Cell, 2014, 53(2):301-16. 

6. Giorgetti L, Servant N, Heard E. Changes in the organization of the genome during the mammalian cell cycle[J]. Genome Biol, 2013, 14(12):142.

7. Seitan VC, Faure AJ, Zhan Y, McCord RP, Lajoie BR, Ing-Simmons E, Lenhard B, Giorgetti L, Heard E, Fisher AG, Flicek P, Dekker J, Merkenschlager M. Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments[J]. Genome Res, 2013, 23(12):2066-77. 

8. de Wit E, Bouwman BA, Zhu Y, Klous P, Splinter E, Verstegen MJ, Krijger PH, Festuccia N, Nora EP, Welling M, Heard E, Geijsen N, Poot RA, Chambers I, de Laat W. The pluripotent genome in three dimensions is shaped around pluripotency factors[J]. Nature, 2013, 501(7466):227-31.   

9. Gendrel AV, Apedaile A, Coker H, Termanis A, Zvetkova I, Godwin J, Tang YA, Huntley D, Montana G, Taylor S, Giannoulatou E, Heard E, Stancheva I, Brockdorff N. Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome[J]. Dev Cell, 2012, 23(2):265-279. 

10. Nora EP, Lajoie BR, Schulz EG, Giorgetti L, Okamoto I, Servant N, Piolot T, van Berkum NL, Meisig J, Sedat J, Gribnau J, Barillot E, Blüthgen N, Dekker J, Heard E. Spatial partitioning of the regulatory landscape of the X-inactivation centre[J].Nature, 2012, 485(7398):381-385. 

11. O'Loghlen A, Muñoz-Cabello AM, Gaspar-Maia A, Wu HA, Banito A, Kunowska N, Racek T, Pemberton HN, Beolchi P, Lavial F, Masui O, Vermeulen M, Carroll T, Graumann J, Heard E, Dillon N, Azuara V, Snijders AP, Peters G, Bernstein E, Gil J. MicroRNA regulation of Cbx7 mediates a switch of Polycomb orthologs during ESC differentiation[J]. Cell Stem Cell, 2012, 10(1):33-46. 

12. Augui S, Nora EP, Heard E. Regulation of X-chromosome inactivation by the X-inactivation centre[J]. Nat Rev Genet, 2011, 12(6):429-442. 

13. Masui O, Bonnet I, Le Baccon P, Brito I, Pollex T, Murphy N, Hupé P, Barillot E, Belmont AS, Heard E. Live-cell chromosome dynamics and outcome of X chromosome pairing events during ES cell differentiation[J]. Cell, 2011, 145(3):447-58. 

14. Okamoto I, Patrat C, Thépot D, Peynot N, Fauque P, Daniel N, Diabangouaya P, Wolf JP, Renard JP, Duranthon V, Heard E. Eutherian mammals use diverse strategies to initiate X-chromosome inactivation during development[J]. Nature, 2011, 472(7343):370-374. 

15. Heard E, Tishkoff S, Todd JA, Vidal M, Wagner GP, Wang J, Weigel D, Young R. Ten years of genetics and genomics: what have we achieved and where are we heading?[J]. Nat Rev Genet, 2010, 11(10):723-733. 

16. Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E. LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation[J]. Cell, 2010, 141(6):956-969. 

17. Nora EP, Heard E. X chromosome inactivation: when dosage counts[J]. Cell2009, 139(5):865-867. 




1. Damm F, Mylonas E, Cosson A, et al. Acquired Initiating Mutations in Early Hematopoietic Cells of CLL Patients[J].Cancer Discov, 2014, 4(9):1088-1101. 
Daniel Gautheret 近年发表文章PubMed链接 >>

2. Lehmann J, Jossinet F, Gautheret D. A universal RNA structural motif docking the elbow of tRNA in the ribosome, RNAse P and T-box leaders[J]. Nucleic Acids Res, 2013, 41(10):5494-5502. 

3. Thiollier C, Lopez CK, Gerby B, et al. Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models[J]. J Exp Med, 2012, 209(11):2017-2031.

4. Ott A, Idali A, Marchais A, Gautheret D. NAPP: the Nucleic Acid Phylogenetic Profile Database[J]. Nucleic Acids Res, 2012, 40(Database issue):D205-209.

5. Naville M, Gautheret D. Premature terminator analysis sheds light on a hidden world of bacterial transcriptional attenuation[J]. Genome Biol, 2010, 11(9):R97.

6. Bohn C, Rigoulay C, Chabelskaya S, et al. Experimental discovery of small RNAs in Staphylococcus aureus reveals a riboregulator of central metabolism[J]. Nucleic Acids Res, 2010, 38(19):6620-6636. 

7. Marchais A, Naville M, Bohn C, Bouloc P, Gautheret D. Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles[J]. Genome Res, 2009, 19(6):1084-1092. 

8. Koscielny G, Le Texier V, Gopalakrishnan C, Gautheret D, et al. ASTD: The Alternative Splicing and Transcript Diversity database[J]. Genomics, 2009, 93(3):213-220. 

10. Espagne E, Lespinet O, Malagnac F, Gautheret D, et al. The genome sequence of the model ascomycete fungus Podospora anserina[J]. Genome Biol2008, 9(5):R77.


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